Chelsea Handler was always a different kind of late-night talk show host and has always had a bit more of an edge to her comedy.

On "Conan," she has always made a few sly remarks to sidekick Andy Richter about his weight.

Andy finally decided he had enough.

There are a lot of good comebacks in the books, and even though the joke was innocuous enough, Andy ended the discussion with his perfectly timed barb that even sent Handler into a fit of laughter.

Source: Free Beer & Hot Wings